Education and Work Experiences：

PhD., Hunan University (2001.9–2004.12)

Postdoc, Tsinghua University (2005.1-2006.12)

Visiting Scholar, University of Florida（2012.12-2013.12）

Research Interests：

The main research directions are biosensing and biochemical analysis. At present, the research work mainly focuses on functional nucleic acid-based biosensing and imaging analysis, the antitumor and antibacterial research of metal-nucleoside nanomaterial.

Awards and Honors:

(1) First Prize for Outstanding Achievement in Scientific and Technological Research of Shaanxi Higher Education Institutions, 2023

(2) Bronze Award of "Fengdong Cup" of Shaanxi Province Science and Technology Workers’s in Innovation and Entrepreneurship Competition, 2019

(3) First Prize in Science and Technology of Shaanxi Higher Education Institutions, 2018

(4) Second Prize in Science and Technology of Shaanxi Province, 2015

(5) First Prize in Science and Technology of Shaanxi Higher Education Institutions, 2014

Research Projects as Principal Investigator:

1. Shaanxi Provincial Natural Science Basic Research Program, Key Project, Grant No. 2025JC-QYXQ-005, "Rational Design of Metal-Nucleobase Nanozymes and Their Antibacterial Research, January 2025 - December 2027, RMB 0.20 million.

2. Shaanxi Provincial Natural Science Basic Research Program, Key Project, Grant No. 2021JZ-23, "Research on Chemiluminescent Point-of-Care Testing for Viral Nucleic Acids", January 2021 - December 2023, RMB 0.10 million.

3. National Natural Science Foundation of China, General Program, Grant No. 21974083, "Research on Novel Barometric Point-of-Care Testing Methods Based on Nanozymes", January 2020 - December 2023, RMB 0.63 million.

4. Fundamental Research Funds for the Central Universities, Key Project, Grant No. GK202002002, "Research on Nanozyme Cascade Catalysis for Tumor Therapy Based on Nucleic Acid Self-Assembly", January 2020 - December 2022, RMB 0.20 million.

5. Fundamental Research Funds for the Central Universities, Innovation Team Project, Grant No. GK201701002, "Innovation Team for Biosensing and Analysis", January 2017 - December 2019, RMB 0.35 million.

6. National Natural Science Foundation of China, General Program, Grant No. 21375086, "Research on Fluorescent Methods for Detecting Telomerase Activity without PCR Amplification, January 2014 - December 2017, RMB 0.80 million.

7. Program for New Century Excellent Talents in University, Grant No. NCET-10-0557, "Screening and Performance Study of Specific Telomerase Inhibitors", January 2011 - December 2013, RMB 0.50 million.

8. National Natural Science Foundation of China, General Program, Grant No. 21075079, "Research on Label-Free Sensors of Heavy Metal Ion Based on Nucleic Acid Aptamers", January 2011 - December 2013, RMB 0.35 million.

9. National Natural Science Foundation of China, General Program, Grant No. 20705017, "Construction of Electrochemical Methods for Studying Interactions Between G-DNA and Small Molecule Ligands", January 2008 - December 2010, RMB 0.18 million.

Representative Publications:

(1) Xinyu Zhu, Zhengtian Wang, Qiaorong Tang, Lu Shi, Baoxin Li, Yan Jin*. Self-assembled DNA micelle-GNP for simultaneous detecting miRNAs of Alzheimer’s disease via lateral flow assays. Biosens. Bioelectron., 2025, 295, 118300. 

(2) Lu Shi, Chaoyong Yang*, Yan Jin*. Advances in gas pressure-based portable biosensing. TrAC Trends in Analytical Chemistry, Trends Anal. Chem., 2024, 180, 117897.

(3) Qiaorong Tang, Caihong Zhou, Lu Shi, Xinyu Zhu, Wei Liu, Baoxin Li, Yan Jin*. Multifunctional manganese-nucleotide laccase-mimicking nanozyme for degradation of organic pollutants and visual assay of epinephrine via smartphone. Anal. Chem., 2024, 96(11), 4736-4744.

(4) Lu Shi, Qiaorong Tang, Bing Yang, Wei Liu, Baoxin Li, Chaoyong Yang, and Yan Jin*, Logic-Gates of Gas Pressure for Portable, Intelligent and Multiple Analysis of Metal Ions. Anal. Chem., 2023, 95(13), 5702-5709. 

(5) Lu Shi, Qiaorong Tang, Bing Yang, Wei Liu, Baoxin Li, Chaoyong Yang, and Yan Jin*. Dual-Mode Logic Gate for Intelligent and Portable Detection of MicroRNA Based on Gas Pressure and Lateral Flow Assay. Anal. Chem., 2023, 95(14), 6090-6097.

(6) Mengmeng Wu, Bing Yang, Lu Shi, Qiaorong Tang, Jing Wang, Wei Liu, Baoxin Li, and Yan Jin*. Peroxidase-mimicking DNAzymes as receptors for label-free discriminating heavy metal ions by chemiluminescence sensor arrays. Anal. Chem., 2023, 95(6), 3486-3492.

(7) Bing Yang, Lu Shi, Qiaorong Tang, Wei Liu, Baoxin Li, Chaoyong Yang and Yan Jin*. Automated study on kinetics and biosensing of glow-type luminescence reaction via digital microfluidics–chemiluminescence, Lab Chip, 2023, 23(4), 785-792.

(8) Bing Yang, Lu Shi, Qiaorong Tang, Wei Liu, Baoxin Li, Chaoyong Yang, Yan Jin*. Automated and label-free detection of HIV DNA via digital microfluidics-chemiluminescence analysis. Sensor. Actuat. B-Chem., 2023, 389, 133905.

(9) Lu Shi, Qiaorong Tang, Bing Yang, Wei Liu, Baoxin Li, Chaoyong Yang, Yan Jin*. Portable and label-free sensor array for discriminating multiple analytes via a handheld gas pressure meter. Anal. Chem., 2022, 94(41), 14453-14459.

(10) Yan Wang, Lu Shi, Jinrui Zhu, Baoxin Li*, Yan Jin*, Visual and sensitive detection of telomerase activity via hydrogen peroxide test strip. Biosens. Bioelectron., 2020,156, 112132.

(11) Jinrui Zhu, Yan Wang, Baoxin Li*, Yan Jin*, Ultra-sensitive and chemiluminescent detection of telomerase activity via handheld luminometer. Sensor. Actuat. B-Chem., 2019, 301, 127109. 

(12) Jing Lei, Lu Shi, Baoxin Li, Chaoyong James Yang, Yan Jin*. Ultrasensitive and portable assay of mercury (II) ions via gas pressure as readout. Biosens. Bioelectron., 2018, 122, 32-36. 

(13) Yanjun Wang, Luzhu Yang, Baoxin Li, Chaoyong James Yang, and Yan Jin*. Point-of-care assay of telomerase activity at single-cell level via gas pressure readout. Anal. Chem., 2017, 89(16), 8311-8318.

(14) Yaocai Wang, Luzhu Yang, Yanjun, Wei Liu, Baoxin Li, Yan Jin*. A sensitive and real-time assay of restriction endonuclease activity and inhibition based on photo-induced electron transfer. Sensor. Actuat. B-Chem., 2017, 252, 477-482.

(15) Xiafei Zhang, Rui Cheng, Zhilu Shi, Yan Jin*. Label-free detection of EcoRI endonuclease activity via fluorescent DNA logic gate. Sensor. Actuat. B-Chem., 2017, 244, 387-392. 

(16) Luzhu Yang, Yanjun Wang, Baoxin Li, Yan Jin*. High-throughput identification of telomere-binding ligands based on the fluorescence regulation of DNA-copper nanoparticles. Biosens. Bioelectron., 2017, 87, 915-917. 

(17) Jing Xu, Yanjun Wang, Luzhu Yang, Yanfang Gao, Baoxin Li, Yan Jin*. A cytometric assay for ultrasensitive and robust detection of human telomerase RNA based on toehold strand displacement. Biosens. Bioelectron., 2017, 87, 1071-1076.

(18) Jing Xu, Yanfang Gao, Baoxin Li, Yan Jin*. Cyclic up-regulation fluorescence of pyrene excimer for studying polynucleotide kinase activity based on dual amplification. Biosens. Bioelectron., 2016, 80, 91-97.

(19) Yan Jin, Qiaorong Tang, "A Cu-Dithiothreitol Nano-Biomimetic Laccase and Its Application in Pollutant Degradation and Epinephrine Detection", China, Patent No. 202210755093.3, June 29, 2022.

(20) Yan Jin, Yanfang Gao, "A Method for Homogeneous Label-Free Detection of Telomerase Activity Based on Triple Amplification Technology", China, Patent No. ZL201510638579.9, October 23, 2018.

(21) Yan Jin, Zhilu Shi, Qi Zhang, "A Method for Screening G-Quadruplex Ligands Based on Photoinduced Electron Transfer", China, Patent No. ZL201510035616.7, July 11, 2017.

(22) Yan Jin, Yaocai Wang, "A Colorimetric Detection Method for Telomerase Activity", China, Patent No. ZL201710044197.2, January 19, 2017.

(23) Yan Jin, Yanjun Wang, "A Method for Point-of-Care Detection of Telomerase Activity Based on Pressure Changes from Platinum Nanoparticle-Catalyzed H₂O₂ Decomposition", China, Patent No. ZL201710034420.5, January 17, 2017.

(24) Yan Jin, Guozhen Chen, Wenhong Wang, "A Label-Free Homogeneous Colorimetric Detection Method for Lead Ions", China, Patent No. ZL201210222117.5, May 14, 2014.

(25) Yan Jin, Wenhong Wang, Yina Zhao, "Hairpin Nucleic Acid Fluorescent Probes and Their Application in Lead Ion Detection", China, Patent No. ZL201210128619.1, September 25, 2013.