
| 刘永春 副研究员 Ass. Reseacher Yongchun Liu Tel: +86-29- E-mail: surfbioliu@snnu.edu.cn |
学习及工作经历:
西安交通大学博士(2013-2017)
陕西师范大学博士后(2018-2022)
研究领域:
蛋白质可控解折叠
奖励及荣誉:
2025,陕西省政府科学技术一等奖
2025,陕西省教育厅高等学校科学技术研究优秀成果特等奖
主持的科研项目:
1.国家重大科研仪器研制专项项目,22427802,柔性纳米膜可控制备研究系统,2025/01-2029/12,782.73万元。
2.国家自然科学基金委员会面上项目, 52473014, 基于蛋白质聚集体的选择性抗生物污染界面设计, 2025/01-2028/12, 49万元。
3.国家自然科学基金委员会青年项目, 51903147, 基于蛋白质可控解折叠与聚集策略的水下生物胶, 2020/01-2022/12, 26万元。
4.陕西省科技厅社会发展领域一般重点项目,2025SF-YBXM-474,蛋白质基融合器时空匹配功能涂层设计,2025/06-2027/05,8万元。
5.中国博士后科学基金面上资助二等, 2019M653864XB, 洋葱状淀粉样蛋白导尿管涂层研制, 2019/01- 2024/01, 8万元。
代表性成果(包括论文、专利、著作等):
1. Li, M.; Zhang, Y.; Liu, Y.; Wang, J.; Zhang, M.; Miao, S.; Tian, J.; Tao, F.; Tian, L.; Li, K.; Yang, P. Redox-Triggered Autologous Protein Assembly for Blood-Contacting Interfaces. ACS Appl. Mater. Interfaces 2026, 18, 14787–14802.
2. Li, L.; Zhang, M.; Wang, J.; Wu, Y.; Tian, L.; Zhang, J.; Chen, H.; Liu, Y.; Yang, P. Bionic Phase-Transitioned α-Lactalbumin Coating for Efficient Separation of Structurally Similar Environmental Endocrine Disruptors by Open Tubular Capillary Electrochromatography. J. Chromatogr. A 2026, 1783, 467121.
3. Zhang, Y.; Ren, H.; Linghu, C.; Zhang, J.; Gao, A.; Su, H.; Miao, S.; Qing, R.; Hu, B.; Chen, X.; Deng, M.; Liu, Y.; Yang, P. Stabilizing Metal Coating on Flexible Devices by Ultra-thin Protein Nanofilms. Adv. Mater. 2024, 36, 2412378.
4. Zhang, M.; Li, K.; Kou, J.; Lu, G.; Qiu, L.; Yang, C.; Liu, Y.; Xue, Q.; Yang, P. Functionalized Amyloid-like Protein Nanofilm Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer. Small Sci. 2024, 4, 2400323.
5. Niu, T.; Mao, Y.; Lv, Y.; Li, M.; Liu, Y.; Yang, P.; Gu, Q. Amyloid-Like Protein-Modified Carbon Nitride as a Bioinspired Material for Enhanced Photocatalytic CO2 Reduction. ACS Appl. Mater. Interfaces 2024, 16, 63495–63508.
6. Pang, Y.; Fu, C.; Zhang, D.; Li, M.; Zhou, X.; Gao, Y.; Lin, K.; Hu, B.; Zhang, K.; Cai, Q.; Yang, P.; Liu, Y.; Zhang, X. Biomimetic Remineralization of Dental Hard Tissues via Amyloid-Like Protein Matrix Composite with Amorphous Calcium Phosphate. Adv. Funct. Mater. 2024, 2403233.
7. Li, L.; Zhang, Y.; Wu, Y.; Wang, Z.; Cui, W.; Zhang, C.; Wang, J.; Liu, Y.; Yang, P. Protein-Based Controllable Nanoarchitectonics for Desired Applications. Adv. Funct. Mater. 2024, 2315509.
8. Liu, Y.; Miao, S.; Ren, H.; Tian, L.; Zhao, J.; Yang, P. Synthesis and Regulation of Versatile 2D Protein Films by Amyloid-Like Aggregation. Nat. Protoc. 2024, 19, 539–564.
9. Liu, Y.; Li, K.; Tian, J.; Gao, A.; Tian, L.; Su, H.; Miao, S.; Tao, F.; Ren, H.; Yang, Q.; Cao, J.; Yang, P. Synthesis of Robust Underwater Glues from Common Proteins via Unfolding-Aggregating Strategy. Nat. Commun. 2023, 14, 5145.
10. Gao, Y.; Pang, Y.; Wei, S.; Han, Q.; Miao, S.; Li, M.; Tian, J.; Fu, C.; Wang, Z.; Zhang, X.; Yang, P.; Liu, Y. Amyloid-Mediated Nanoarchitectonics with Biomimetic Mineralization of Polyetheretherketone for Enhanced Osseointegration. ACS Appl. Mater. Interfaces 2023, 15, 10426–10440.
11. Zhang, Y.; Liu, Y.; Liu, Y.; Zuo, P.; Miao, S.; Hu, B.; Kang, Y.; Liu, W.; Yang, Q.; Ren, H.; Yang, P. α-Helix-Mediated Protein Adhesion. J. Am. Chem. Soc. 2023, 145, 17125–17135.
12. Su, H.; Liu, Y.; Gao, Y.; Fu, C.; Li, C.; Qin, R.; Liang, L.; Yang, P. Amyloid-Like Protein Aggregation Toward Pesticide Reduction. Adv. Sci. 2022, 9, 2105106.
13. Zhang, C.; Jiang, X.; Yu, F.; Liu, Y.; Yue, Q.; Yang, P.; Liu, Y. Antagonistic Action Regulated Anti-Etching Colorimetric Detection of Thiram Residue in Soil Based on Triangular Silver Nanoplates. Sens. Actuators, B 2021, 344, 130304.
14. Liu, Y.; Tao, F.; Miao, S.; Yang, P. Controlling the Structure and Function of Protein Thin Films through Amyloid-like Aggregation. Acc. Chem. Res. 2021, 54, 3016–3027.
15. Yan, X.; Liu, Y.; Hu, X.; Qin, R.; Su, H.; Li, J.; Yang, P. The Synthesis of a 2D Ultralarge Protein Supramolecular Nanofilm by Chemoselective Thiol-Disulfide Exchange and its Emergent Functions. Angew. Chem., Int. Ed. 2020, 59, 2850–2859.