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李正平 教授 Prof. Zhengping Li Tel: +86-29-81530859 E-mail: lzpbd@snnu.edu.cn |
研究方向:
生化分析与分子诊断
核酸、蛋白质生物标志物的高灵敏度分析与疾病诊断
微纳界面的生物传感分析
单细胞分析及高通量核酸测序分析研究。
社会职务:
《分析化学》编委
国家基金委评委
简历:
1999年在北京大学获得理学博士学位
2000-2002年在日本日立中央研究所从事博士后研究
2002-2013年河北大学教授、博士生导师
2013-2016年陕西师范大学教授、博士生导师
科研业绩:
基于核酸扩增及纳米粒子探针信号放大技术,系统研究建立了基因突变、DNA甲基化、microRNA及mRNA的高灵敏度分析方法,基于单微球表面成像实现了生物标志的单分子、单细胞分析。先后主持国家杰出青年基金,国家自然科学基金重点项目及可控自组装及其功能化重大研究计划等20余项科研项目。在JACS, Angew. Chem. Int. Ed., Chem. Sci., Chem. Commun., Anal., Chem.等杂志发表论文80余篇。
获得奖励/专利:
“利用分子发光技术研究高灵敏度分子诊断分析”获得河北省自然科学一等奖。
代表性论文论著:
1、 Xinrui Duan, Zhengping Li*, Fang He, Shu Wang*, A Sensitive and Homogeneous SNP Detection Using Cationic Conjugated Polymers, Journal of American Chemical Society, 2007, 129, 4154-4155.
2、 Bao-An Du, Zheng-Ping Li*, Cheng-Hui Liu, One-step Homogeneous Detection of DNA Hybridization with Gold Nanoparticle Probes by Using a Linear Light Scattering Technique, Angewandte Chemie International Edition, 2006, 45, 8022-8025.
3、 Yongqiang Cheng, Xian Zhang, Zhengping Li*, Xiaoxia Jiao, Yucong Wang, Yali Zhang, Highly Sensitive Determination of microRNA Using Target-Primed and Branched Rolling Circle Amplification, Angewandte Chemie International Edition, 2009, 48, 3268-3272.
4、 Hongxia Jia, Zhengping Li*, Chenghui Liu, Yongqiang Cheng, Ultrasensitive Detection of microRNAs with Exponentially Isothermal Amplification, Angewandte Chemie International Edition, 2010, 49, 5498-5501.
5、 Xiaobo Zhang, Chenghui Liu,* Honghong Wang, Hui Wang, Zhengping Li*, Highly-Concentrated Fluorescence Enrichment on a Single Microbead: An Ultrasensitive Strategy for the Detection of Protein Kinase Activity at Single-Cell Level. Angewandte Chemie International Edition, 2015, 54, 15186-15190.
6、 Fengxia Su, Limei Wang, Yueying Sun, Chenghui Liu, Xinrui Duan and Zhengping Li*, Highly sensitive and multiplexed analysis of CpG methylation at single-base resolution with ligationbased exponential amplification,Chemical Science,2015, 2015, 6, 1866-1872.
7、 Xiaobo Zhang, Chenghui Liu,* Lingbo Sun, Xinrui Duan and Zhengping Li*, Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level, Chemical Science, 2015, 6, 6213-6218.
8、 Honghong Wang, Hui Wang, Chenghui Liu,* Xinrui Duan and Zhengping Li*, Ultrasensitive detection of telomerase activity in a single cell using stem-loop primer-mediated exponential amplification (SPEA) with near zero nonspecific signal, Chemical Science, 2016, 7, 4945-4950.
9、 Hui Tian, Yuanyuan Sun, Chenghui Liu,* Xinrui Duan, Wei Tang, and Zhengping Li*,Precise Quantitation of MicroRNA in a Single Cell with Droplet Digital PCR Based on Ligation Reaction,Analytical Chemistry,2016, 88, 11384-11389.
10、 Pengbo Zhang, Jiangyan Zhang, Chengli Wang, Chenghui Liu,* Hui Wang, and Zhengping Li*, Highly Sensitive and Specific Multiplexed MicroRNA Quantification Using Size-Coded Ligation Chain Reaction. Analytical Chemistry, 2014, 86, 1076−1082.