学习及工作经历（从博士开始）：

湖南大学博士（2001.9–2004.12）

清华大学博士后（2005.1-2006.12）

陕西师范大学化学化工学院副教授（2005.12-2011.12）

美国佛罗里达大学访问学者（2012.12-2013.12）

陕西师范大学化学化工学院教授（2011.12-至今）

研究领域：

研究方向为生物传感及生化分析。目前主要从事基于功能核酸的生物传感与成像分析、金属-核苷基纳米材料的抗肿瘤与抗菌研究。

奖励及荣誉：

2023, 陕西高等学校科学技术研究优秀成果奖 一等奖

(1) 2019,“沣东杯”陕西省科技工作者创新创业大赛铜奖

(2) 2018, 陕西省高等学校科学技术奖 一等奖

(3) 2015, 陕西省科学技术奖二等奖

(4) 2014, 陕西省高等学校科学技术奖 一等奖

主持的科研项目：

1. 陕西省自然科学基础研究计划 重点项目，2025JC-QYXQ-005，金属-核苷基纳米酶的理性设计及其抗菌性能研究，2025/01-2027/12, 20.00万元。

2. 陕西省自然科学基础研究计划 重点项目，2021JZ-23，病毒核酸化学发光即时检测法研究，2021/01-2023/12，10.00 万元。

3. 国家自然科学基金 面上项目，21974083，基于纳米酶的气压型即时检测新方法研究，2020/01-2023/12，63.00万元。

4. 中央高校 重点项目，GK202002002，基于核酸自组装的纳米酶连锁催化肿瘤治疗研究，2020/01-2022/12，20.00 万元。

5. 中央高校 创新团队项目，GK201701002，生物传感与分析创新团队，2017/01-2019/12，35.00万元。

6. 国家自然科学基金 面上项目，21375086，无需PCR扩增端粒酶检测荧光法的研究，2014/01-2017/12，80.00万元。

7. 教育部新世纪优秀人才支持计划，NCET-10-0557，专一性端粒酶抑制剂的筛选及性能研究，2011/01-2013/12，50.00万元。

8. 国家自然科学基金，面上项目，21075079，基于核酸适配体非标记型重金属离子传感器的研究，2011/01-2013/12，35.00 万元。

9. 国家自然科学基金 面上项目，20705017，G-DNA 与小分子配体相互作用的电化学研究方法构建，2008/01-2010/12, 18.00 万元。

代表性成果（论文、专利、著作等）：

(1) Xinyu Zhu, Zhengtian Wang, Qiaorong Tang, Lu Shi, Baoxin Li, Yan Jin*. Self-assembled DNA micelle-GNP for simultaneous detecting miRNAs of Alzheimer’s disease via lateral flow assays. Biosens. Bioelectron., 2025, 295, 118300.

(2) Lu Shi, Chaoyong Yang*, Yan Jin*. Advances in gas pressure-based portable biosensing. TrAC Trends in Analytical Chemistry, Trends Anal. Chem., 2024, 180, 117897.

(3) Qiaorong Tang, Caihong Zhou, Lu Shi, Xinyu Zhu, Wei Liu, Baoxin Li, Yan Jin*. Multifunctional manganese-nucleotide laccase-mimicking nanozyme for degradation of organic pollutants and visual assay of epinephrine via smartphone. Anal. Chem., 2024, 96(11), 4736-4744.

(4) Lu Shi, Qiaorong Tang, Bing Yang, Wei Liu, Baoxin Li, Chaoyong Yang, and Yan Jin*, Logic-Gates of Gas Pressure for Portable, Intelligent and Multiple Analysis of Metal Ions. Anal. Chem., 2023, 95(13), 5702-5709.

(5) Lu Shi, Qiaorong Tang, Bing Yang, Wei Liu, Baoxin Li, Chaoyong Yang, and Yan Jin*. Dual-Mode Logic Gate for Intelligent and Portable Detection of MicroRNA Based on Gas Pressure and Lateral Flow Assay. Anal. Chem., 2023, 95(14), 6090-6097.

(6) Mengmeng Wu, Bing Yang, Lu Shi, Qiaorong Tang, Jing Wang, Wei Liu, Baoxin Li, and Yan Jin*. Peroxidase-mimicking DNAzymes as receptors for label-free discriminating heavy metal ions by chemiluminescence sensor arrays. Anal. Chem., 2023, 95(6), 3486-3492.

(7) Bing Yang, Lu Shi, Qiaorong Tang, Wei Liu, Baoxin Li, Chaoyong Yang and Yan Jin*. Automated study on kinetics and biosensing of glow-type luminescence reaction via digital microfluidics–chemiluminescence, Lab Chip, 2023, 23(4), 785-792.

(8) Bing Yang, Lu Shi, Qiaorong Tang, Wei Liu, Baoxin Li, Chaoyong Yang, Yan Jin*. Automated and label-free detection of HIV DNA via digital microfluidics-chemiluminescence analysis. Sensor. Actuat. B-Chem., 2023, 389, 133905.

(9) Lu Shi, Qiaorong Tang, Bing Yang, Wei Liu, Baoxin Li, Chaoyong Yang, Yan Jin*. Portable and label-free sensor array for discriminating multiple analytes via a handheld gas pressure meter. Anal. Chem., 2022, 94(41), 14453-14459.

(10) Yan Wang, Lu Shi, Jinrui Zhu, Baoxin Li*, Yan Jin*, Visual and sensitive detection of telomerase activity via hydrogen peroxide test strip. Biosens. Bioelectron., 2020,156, 112132.

(11) Jinrui Zhu, Yan Wang, Baoxin Li*, Yan Jin*, Ultra-sensitive and chemiluminescent detection of telomerase activity via handheld luminometer. Sensor. Actuat. B-Chem., 2019, 301, 127109.

(12) Jing Lei, Lu Shi, Baoxin Li, Chaoyong James Yang, Yan Jin*. Ultrasensitive and portable assay of mercury (II) ions via gas pressure as readout. Biosens. Bioelectron., 2018, 122, 32-36.

(13) Yanjun Wang, Luzhu Yang, Baoxin Li, Chaoyong James Yang, and Yan Jin*. Point-of-care assay of telomerase activity at single-cell level via gas pressure readout. Anal. Chem., 2017, 89(16), 8311-8318.

(14) Yaocai Wang, Luzhu Yang, Yanjun, Wei Liu, Baoxin Li, Yan Jin*. A sensitive and real-time assay of restriction endonuclease activity and inhibition based on photo-induced electron transfer. Sensor. Actuat. B-Chem., 2017, 252, 477-482.

(15) Xiafei Zhang, Rui Cheng, Zhilu Shi, Yan Jin*. Label-free detection of EcoRI endonuclease activity via fluorescent DNA logic gate. Sensor. Actuat. B-Chem., 2017, 244, 387-392.

(16) Luzhu Yang, Yanjun Wang, Baoxin Li, Yan Jin*. High-throughput identification of telomere-binding ligands based on the fluorescence regulation of DNA-copper nanoparticles. Biosens. Bioelectron., 2017, 87, 915-917.

(17) Jing Xu, Yanjun Wang, Luzhu Yang, Yanfang Gao, Baoxin Li, Yan Jin*. A cytometric assay for ultrasensitive and robust detection of human telomerase RNA based on toehold strand displacement. Biosens. Bioelectron., 2017, 87, 1071-1076.

(18) Jing Xu, Yanfang Gao, Baoxin Li, Yan Jin*. Cyclic up-regulation fluorescence of pyrene excimer for studying polynucleotide kinase activity based on dual amplification. Biosens. Bioelectron., 2016, 80, 91-97.

(19) Yan Jin, Qiaorong Tang, "A Cu-Dithiothreitol Nano-Biomimetic Laccase and Its Application in Pollutant Degradation and Epinephrine Detection", China, Patent No. 202210755093.3, June 29, 2022.

(20) Yan Jin, Yanfang Gao, "A Method for Homogeneous Label-Free Detection of Telomerase Activity Based on Triple Amplification Technology", China, Patent No. ZL201510638579.9, October 23, 2018.

(21) Yan Jin, Zhilu Shi, Qi Zhang, "A Method for Screening G-Quadruplex Ligands Based on Photoinduced Electron Transfer", China, Patent No. ZL201510035616.7, July 11, 2017.

(22) Yan Jin, Yaocai Wang, "A Colorimetric Detection Method for Telomerase Activity", China, Patent No. ZL201710044197.2, January 19, 2017.

(23) Yan Jin, Yanjun Wang, "A Method for Point-of-Care Detection of Telomerase Activity Based on Pressure Changes from Platinum Nanoparticle-Catalyzed H₂O₂ Decomposition", China, Patent No. ZL201710034420.5, January 17, 2017.

(24) Yan Jin, Guozhen Chen, Wenhong Wang, "A Label-Free Homogeneous Colorimetric Detection Method for Lead Ions", China, Patent No. ZL201210222117.5, May 14, 2014.

(25) Yan Jin, Wenhong Wang, Yina Zhao, "Hairpin Nucleic Acid Fluorescent Probes and Their Application in Lead Ion Detection", China, Patent No. ZL201210128619.1, September 25, 2013.