（第 17 号）
报告题目：Mechanistic Development of the Lucite ALPHA Process and other Pd-diphosphineCatalyzedMethoxycarbonylations
报告人：Dr. Jonathan Iggo
Department of Chemistry, University of Liverpool, Liverpool, U.K.
The Lucite ALPHA process for the manufacture of methyl methacrylate (MMA) uses radically different chemistry from the conventional acetone cyanohydrin (ACH) process. Commercialization of the process was critically dependent on improvements in catalyst lifetime. Identification of the reaction intermediates, resting states and catalyst decay processes by Iggo, Heaton, and Whyman provided crucial direction in the development of the process and the adoption of counter-intuitive process conditions. This resulted in the successful commercialization of this new process. This lecture will describe this and related mechanistic work.
After completing his PhD with Dr Martin Mays at the University of Cambridge, U.K. and a post-doc with Prof Bernard Shaw at the University of Leeds, Dr. Iggo joined the Faculty at the Queens University of Belfast as a “New Blood” lecturer before moving to the University of Liverpool where he is currently a Senior Lecture in the Department of Chemistry. With Prof. Heaton, Iggo set up the Liverpool High Pressure Spectroscopy Group. DrIggo's research interests are focused on in and ex situ and in operando studies of mechanism in organometallic catalysis; Iggo developed the world’s first, practicable, NMR system for studying working organometallic catalysts where one or more substrate is a gas and was closely involved in the development of the Lucite ALPHA Process for methyl methacrylate. Iggo also works with Xiao on understanding the mechanism of asymmetric hydrogens and transfer hydrogenations. More recently Iggo (with Wallace) has been developing chemical shift imaging with chemical shift gradients to study reactions occurring along a chemical gradient and has applied this technique to study the formation of gels and the interactions of guest molecules with the gel fibres.