应用表面与胶体化学教育部重点实验室

成立十周年学术报告

（第002号）

报告题目：

Kinetics of Protein Aggregation

报告人：

Tuomas P. J. Knowles

Department of Chemistry and Cavendish Laboratory

University of Cambridge

主持人：

杨鹏教授

报告时间：

2017年5月25日上午10点

报告地点：

陕西师范大学长安校区致知楼化学化工学院六层报告厅1668室

简 介：

Tuomas Knowles studied Biology at the University of Geneva and Physics at ETH Zurich from where he graduated in 2004. He obtained a Ph.D. in Biological Physics from the University of Cambridge in 2008 and joined the faculty at the Department of Chemistry at Cambridge in 2010 where he is currently professor of Physical Chemistry and Biophysics. His work is focused on the development and application of experimental and theoretical methods based on the physical sciences to study biomolecular behaviour and interactions in the context of both biological function and malfunction.

Filamentous protein aggregation underlies a number of functional and pathological processes in nature. This talk focuses on the formation of amyloid fibrils, a class of beta-sheet rich protein filament. Such structures were initially discovered in the context of disease states where their uncontrolled formation impedes normal cellular function, but are now known to also possess numerous beneficial roles in organisms ranging from bacteria to humans. The formation of these structures commonly occurs through supra-molecular polymerisation following an initial primary nucleation step. In recent years it has become apparent that in addition to primary nucleation, secondary nucleation events which are catalysed the the presence of existing aggregates can play a significant role in the dynamics of such systems. This talk describes our efforts to understand the nature of the nucleation processes in protein aggregation as well as the dynamics of such systems and how these features connect to the biological roles that these structures can have in both health and disease.

应用表面与胶体化学教育部重点实验室

应用表面与胶体化学创新引智基地

化学化工学院

2017年5月23日